Screw eSata, go Infiniband.
From what I can tell, most drives can't fill an eSata pipe anyway
my drives can, you just gotta use this special software called bonzai buddy. it tweaks everything on your computer so it's all super fast.
that bonzai buddy shit is freal
it can asynchronously multiplex your kb drivers so you can fantabulate any 5d image as easily as ms paint
For something I/O heavy I'd guess... video editing/encoding or some shit.