I think overall the isolation is bad for society in the long run and will result in an even wider gap between the haves and have nots. Like a butterfly effect. If we had been able to be as isolationist as we have to be now all along, I seriously doubt the world would be the same place it is now and not for the better.
It would completely rule out the possibility of a future that resembles anything like Gene Roddenberry’s vision. No matter how much people try to separate, we are a collectivist society and have to be if survival and happiness matter at all.